Establishing Population Pharmacokinetic Model for Ethambutol on Pulmonary Tuberculosis Patients

The population pharmacokinetic model of ethambutol with covariates was built from data 136 pulmonary tuberculosis patients recruited 3 hospitals: Hanoi Lung Hospital, Central Hospital 74, and Hospital. Blood samples were obtained on the 10-14th day after initiation treatment for plasma drug analysis by LC-MS/MS method. Time - concentration processed method non-linear mixed effect modeling MONOLIX 2021R1 software. final is a two-compartment model, sequential zero (with prior lag time Tk01) followed first-order absorption, linear elimination. volumes distribution central peripheral compartments respectively 6.73 L 1250 L; clearance value Cl 45.8 L/h. Janmahasatian’s Fat-free mass age found to be influential inter-individual variability clearance.